An acute sense of observation sharpened for many years!
Keywords : Parasitoid wasps, Polydnavirus, Venoms of Hymenoptera, Insect immunity, integrative biology.
A pteromalid parasitoid emerged from a gall of Andricus quercuscalicis
Parasitoid Hymenoptera are developing at the expense of a host which will necessarily be killed at the end of their development. The issue of the physiological relationships between a parasitoid and its host depends on their respective abilities to implement strategies of virulence or resistance against the adverse organism. Strategies of virulence are genetically determined and placed under constant and strong selective pressures. They tend to optimize the survival of parasitoid eggs under important physiological constraints mainly imposed by the host’s development and immune system.
Numerous works have described the physiological effects of the main factors of virulence of parasitoid Hymenoptera (polydnaviruses, virus-like particles, venom, ovarian secretions, larval salivary secretions, teratocytes…). Awareness about the protein composition of these factors (or proteins encoded by them in the case of polydnaviruses) is increasing. However, few authors focused on understanding the functional evolution of these proteins of virulence. This constitutes one of my main centers of interest.
My general orientation consists in using molecular biology, bioinformatics, biochemistry and microscopy tools to characterize the main functions and evolutionary patterns of factors of virulence from parasitoid wasps (polydnaviruses and venom). The biological model I’m currently working on is Cotesia congregata (Hymenoptera: Braconidae) which develops as a gregarious larval endoparasitoid of the tobacco hornworm Manduca sexta. I have also worked directly or through collaborations on other hymenopteran species such as Asobara tabida, Asobara citri, Chelonus inanitus and Leptopilina boulardi.
Slideshow performed for the BioSyst.EU 2013 Global systematics meeting, Vienna, February 18th to 22nd 2013.
 Moreau SJM. (2013) "It stings a bit but it cleans well": Venoms of Hymenoptera and their antimicrobial potential. J. Insect Physiol., 59:186-204.
 Huguet E, Serbielle C, Moreau SJM.(2012) Evolution and origin of polydnavirus virulence genes. In Beckage NE, Drezen JM (Eds.) Parasitoid viruses: symbionts and pathogens. Academic Press, London, UK, pp. 63-78.
 Prévost G, Eslin P, Cherqui A, Moreau SJM, Doury G. (2012) When parasitoids lack polydnaviruses, can venoms subdue the hosts ? The case study of Asobara species. In Beckage NE, Drezen JM (Eds.) Parasitoid viruses: symbionts and pathogens. Academic Press, London, UK, 255-266.
 Vincent B, Kaeslin M, Roth T, Heller M, Poulain J, Cousserans F, Schaller J, Poirié M, Lanzrein B, Drezen JM, Moreau SJM. (2010) The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach. BMC Genomics, 11: 693.
 Vinchon S, Moreau SJM, Cherqui A, Drezen JM, Prévost G. (2010) Molecular and biochemical analysis of an aspartylglucosaminidase from the venom of the parasitoid wasp Asobara tabida (Hymenoptera: Braconidae). Insect Biochem. Mol. Biol., 40:38-48.
 Moreau SJM, Cherqui A, Prévost G. (2009) Components of Asobara venoms and their effects on hosts. In Prévost G (Ed.) Advances in Parasitology, Volume 70, Burlington: Academic Press, London & New York, pp. 217-232.
 Moreau SJM, Huguet E, Drezen JM (2009) Polydnaviruses as tools to deliver wasp virulence factors to impair lepidopteran host immunity. In Reynolds S. (Ed), Insect Infection and Immunity: Evolution, Ecology and Mechanisms. Oxford University Press, Oxford, UK, pp. 137-158.
 Serbielle C, Moreau S, Veillard F, Voldoire E, Bézier A, Mannucci M-A, Volkoff A-N, Drezen JM, Lalmanach G, Huguet E. (2009) Identification of parasite-responsive cysteine proteases in Manduca sexta. Biol. Chem., 390:493-502.
 Colinet D, Dubuffet A, Cazes D, Moreau S, Drezen J-M, Poirié M. (2009) A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Dev. Comp. Immunol., 33: 681-689.
 Moreau SJM, Guillot S. (2005) Advances and prospects on biosynthesis, structures and functions of venom proteins from parasitic wasps. Insect Biochem. Molec. Biol., 35:1209-1223.
 Prévost G, Eslin P, Doury G, Moreau SJM, Guillot S. (2005) Asobara, braconid parasitoids of Drosophila larvae: unusual strategies to avoid encapsulation without VLPs. J. Insect Physiol., 51:171-179.
 Moreau SJM, Guillot S, Populaire C, Doury G, Prévost G, Eslin P. (2005) Conversely to its sibling Drosophila melanogaster, D. simulans overcomes the immunosuppressive effects of the parasitoid Asobara citri. Dev. Comp. Immunol., 29:205-209.
 Roussel J, Moreau SJM, Duverlie G, Dubuisson J, Wychowski C. (2004) Analyse du décalage ribosomique à l'origine de la synthèse de la protéine F du Virus de l'Hépatite C de génotype 1a. Virologie, 8:S45.
 Moreau SJM, Cherqui A, Dubois F, Doury G, Fourdrain Y, Bulet P, Sabatier L, Saarela J, Prévost G, Giordanengo P. (2004) Identification of an aspartylglucosaminidase-like protein in the venom of the parasitic wasp Asobara tabida (Hymenoptera: Braconidae). Insect Biochem. Molec. Biol., 34:485-492.
 Moreau SJM. (2003) Relationships between parasitoid Hymenoptera and the immune system of their hosts: The « active » and « passive » mechanisms redefined. Ann. Soc. Entomol. Fr., 39:305-314.
 Moreau SJM, Eslin P, Doury G. (2003) Comparative study of the strategies evolved by two parasitoids of the Asobara genus to avoid the immune response of the host, Drosophila melanogaster. Dev. Comp. Immunol., 27:273-282.
 Moreau SJM, Dingremont A, Doury G, Giordanengo P. (2002) Effects of parasitism by Asobara tabida (Hymenoptera: Braconidae) on the development, survival and activity of Drosophila melanogaster larvae. J. Insect Physiol., 48:337-347.
 Moreau SJM, Doury G, Giordanengo P. (2000) Intraspecific variation in the effects of parasitism by Asobara tabida on phenoloxidase activity of Drosophila melanogaster larvae. J. Invertebr. Pathol., 76:151-153.