Photo de Papillon
Photo de Coccinelle
Institut de
Recherche sur la
Biologie de l'
You are here : English / People


Assistant Professor
Team: Relations Multitrophiques
Tél : 02 47 367349

Research theme:

After a Master of microbiology, plant science and biotechnology (MBVB ) obtained from the Aix-Marseille University (Marseille, France), I actually started my research career by a PhD Thesis in the Plant-Nematode Interactions team (IPN), Institut Sophia Agrobiotech, INRA, Sophia-Antipolis. During my thesis, I have focused my research on getting a global view of root-knot nematode genes regulated during the early steps of parasitism and developing a valid tool for the functional analysis of genes issued from genomic and transcriptomic data. I deepen the differences between the transcriptome of pre-parasitic exophyte stage and sedentary endophyte stage of M.  incognita and showed the implication of nematode secretions involved in the adaptation of the parasite to its host environment and the effectors involved in the modulation of host responses. Secreted detoxification enzymes could protect the nematode from reactive oxygen species or modulate the plant responses triggered by the pathogen attack.

I continued my research activity in the Regulation of Gene Expression and Epigenetics Laboratory (LREGE), Integrative Biology and Molecular Genetics Department in the Institute of Biology and Technology in Saclay. During this period, I have mainly focused my research on gene regulation expression in yeast. Particularly, I identified chromatin remodeling complexes involved in the regulation of RNa polymerase III transcription and contributed in a project that revealed the role of a non-histone chromatin-associated protein in the stimulation of the RNA polymerase III transcription.


In 2010, I joined the ‘Insect Defense” team (ID) at INRA in Sophia-Antipolis. During this postdoctoral position, I have being studying aphid immunity. Analysis of the pea aphid genome revealed the absence of genes known to be involved in the immune responses of other insects. However, in contrast to this apparent limitation in the anti-microbial arsenal, I identified 5 genes coding for macrophage migration inhibitory factors. In human, Macrophage Migration Inhibitory Factor (MIF) pleiotropic molecules acting on key cellular processes such as cell proliferation and apoptosis, and are therefore involved in numerous pathologies including cancer, systemic infections and sepsis, autoimmune diseases, and metabolic disorders. By a phylogenetic analysis, we showed that aphid mif genes are clustered into five clades among which four clades are specific to aphididae. Acyrthosiphon pisum mif expression levels differentially vary during agonistic or antagonistic interactions supporting the hypothesis of a role of immune regulators for Apmif.


Image d'illustration

Major publications

 2014       Dubreuil G, Deleury E, Crochard D, Simon JC, Coustau C. Diversification of MIFimmune regulators in aphids: link with agonistic and antagonistic interactions. BMC Genomics. 2014 Sep 5;15:762. doi: 10.1186/1471-2164-15-762.  

2013       Baron OL, van West P, Industri B, Ponchet M, Dubreuil G, Gourbal B, Reichhart JM, Coustau C. Parental transfer of the antimicrobial protein LBP/BPI protectsBiomphalaria glabrata eggs against oomycete infections. PLoS Pathog. 2013;9(12):e1003792. doi: 10.1371/journal.ppat.1003792.  

2013       Body M, Kaiser W, Dubreuil G, Casas J, Giron D. Leaf-miners co-optmicroorganisms to enhance their nutritional environment. J Chem Ecol. 2013 Jul;39(7):969-77. doi: 10.1007/s10886-013-0307-y.  

2012       Deleury E, Dubreuil G, Elangovan N, Wajnberg E, Reichhart JM, Gourbal B, Duval D, Baron OL, Gouzy J, Coustau C. Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study. PLoSOne. 2012;7(3):e32512. doi: 10.1371/journal.pone.0032512.  

2011       Dubreuil G, Deleury E, Magliano M, Jaouannet M, Abad P, Rosso MN. Peroxiredoxins from the plant parasitic root-knot nematode, Meloidogyne incognita, are required for successful development within the host. Int J Parasitol. 2011 Mar;41(3-4):385-96. doi: 10.1016/j.ijpara.2010.10.008.  

2009       Tavenet A, Suleau A, Dubreuil G, Ferrari R, Ducrot C, Michaut M, Aude JC, Dieci G, Lefebvre O, Conesa C, Acker J. Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14265-70. doi: 10.1073/pnas.0900162106.

 2009       Dubreuil G, Magliano M, Dubrana MP, Lozano J, Lecomte P, Favery B, Abad P, Rosso MN. Tobacco rattle virus mediates gene silencing in a plant parasitic root-knot nematode. J Exp Bot. 2009;60(14):4041-50. doi: 10.1093/jxb/erp237.

 2008       Caillaud MC, Dubreuil G, Quentin M, Perfus-Barbeoch L, Lecomte P, de Almeida Engler J, Abad P, Rosso MN, Favery B. Root-knot nematodes manipulate plant cell functions during a compatible interaction. J Plant Physiol. 2008 Jan;165(1):104-13.

 2007       Dubreuil G, Magliano M, Deleury E, Abad P, Rosso MN. Transcriptome analysis of root-knot nematode functions induced in the early stages of parasitism. New Phytol. 2007;176(2):426-36

Photo de fourmi